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Managing diabetic nephropathy: recent studies.
Curr Opin Nephrol Hypertens ; 15(2): 111-6, 2006 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-16481875
ABSTRACT
PURPOSE OF REVIEW This review summarizes recent studies designed to identify improved treatments for diabetic nephropathy. RECENT

FINDINGS:

Recent data support the concept that angiotensin converting enzyme inhibitors and angiotensin II receptor blockers have similar renoprotective effects. Aggressive blockade of the renin-angiotensin system appears to have benefits beyond those achieved with conventional doses of single agents. Dual blockade using angiotensin converting enzyme inhibitors and angiotensin II receptor blockers is effective. Aldosterone receptor antagonists may potentiate the effect of these two classes of compounds. It remains unclear, however, whether maximum benefit can be obtained by the combination of angiotensin converting enzyme inhibitors and angiotensin II receptor blockers or aldosterone receptor antagonists as compared to larger doses of single agents. Not enough data are available currently to recommend thiazolidinedione hypoglycemic agents for renal protection. Trials are being conducted with several new classes of agents.

SUMMARY:

Evidence from short-term studies favors aggressive blockade of the renin-angiotensin system. Long-term studies, however, remain to be performed. A multifactorial approach that incorporates established interventions affords our best means to retard the progression of diabetic nephropathy.
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Coleções: Bases de dados internacionais Base de dados: MEDLINE Assunto principal: Inibidores da Enzima Conversora de Angiotensina / Bloqueadores dos Canais de Cálcio / Nefropatias Diabéticas / Diuréticos Tipo de estudo: Ensaio clínico controlado Aspecto clínico: Diagnóstico / Etiologia / Prognóstico / Terapia Limite: Feminino / Humanos / Masculino Idioma: Inglês Revista: Curr Opin Nephrol Hypertens Assunto da revista: Angiologia / Nefrologia Ano de publicação: 2006 Tipo de documento: Artigo País de afiliação: Estados Unidos