Efficacy and costs of 3 anesthetic regimens in the prevention of postoperative nausea and vomiting.
J Clin Anesth
; 18(1): 41-5, 2006 Feb.
Article
em En
| MEDLINE
| ID: mdl-16517331
ABSTRACT
STUDY OBJECTIVE:
The aim of the study was to compare the antiemetic efficacy and costs associated with 3 different anesthesia regimens used in gynecologic laparoscopy.DESIGN:
This was a randomized, controlled study.SETTING:
The study was conducted at a university hospital. PATIENTS We studied 150 ASA physical status I or II patients, undergoing elective gynecologic laparoscopy with general anesthesia. INTERVENTION Patients were allocated into the following 3 groups group P-preoperative placebo tablet, propofol induction, propofol-air/O2 maintenance; group I + O-preoperative 8-mg ondansetron tablet, thiopental induction, isoflurane-N2O maintenance; group I (control)-preoperative placebo tablet, thiopental induction, isoflurane-N2O maintenance. MEASUREMENTS The frequency of postoperative nausea and vomiting (PONV), number needed to treat to prevent PONV, and the costs of the anesthetic drugs to prevent PONV in one additional patient were evaluated. MAINRESULTS:
The frequency of PONV within the 24-hour study period was lowest in group I + O (P, 38%; I + O, 33%; and I, 59%; P < 0.05 I + O vs I). The number needed to treat was 5 in group P and 4 in group I + O, compared with group I. The median costs of anesthetic drugs to prevent PONV in one additional patient were $65 in group P and dollar 68 in group I + O, compared with group I.CONCLUSIONS:
We conclude that in gynecologic laparoscopy, propofol-air/O2 anesthesia alone, and isoflurane-N2O anesthesia combined with an oral 8-mg dose of ondansetron had similar efficacy and costs to prevent PONV. Isoflurane-N2O anesthesia without ondansetron was less expensive, but was also less efficacious.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ondansetron
/
Anestésicos Intravenosos
/
Anestésicos Inalatórios
/
Náusea e Vômito Pós-Operatórios
/
Anestesia Geral
/
Antieméticos
Tipo de estudo:
Clinical_trials
/
Health_economic_evaluation
Limite:
Adult
/
Female
/
Humans
Idioma:
En
Revista:
J Clin Anesth
Assunto da revista:
ANESTESIOLOGIA
Ano de publicação:
2006
Tipo de documento:
Article
País de afiliação:
Finlândia
País de publicação:
EEUU
/
ESTADOS UNIDOS
/
ESTADOS UNIDOS DA AMERICA
/
EUA
/
UNITED STATES
/
UNITED STATES OF AMERICA
/
US
/
USA