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Endogenous stem and precursor cells for demyelinating diseases: an alternative for transplantation?
Neurol Res; 28(5): 513-7, 2006 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-16808881
ABSTRACT
Remyelination can be very effective in human. However, this process ultimately fails in multiple sclerosis (MS). In this paper, we discuss the possibility of stimulating endogenous oligodendrocyte precursors to participate in remyelination in experimental models (rat and primate Callithrix jacchus) of MS through thyroid hormone (TH) administration. TH is in fact known to be a key signal in brain development, oligodendrocyte development and myelin protein gene expression regulation.
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Coleções: Bases de dados internacionais Base de dados: MEDLINE Assunto principal: Células-Tronco / Hormônios Tireóideos / Encéfalo / Oligodendroglia / Doenças Desmielinizantes Limite: Animais / Humanos Idioma: Inglês Revista: Neurol Res Ano de publicação: 2006 Tipo de documento: Artigo País de afiliação: Itália