Efficacy of gene therapy-delivered cytosine deaminase is determined by enzymatic activity but not expression.
Br J Cancer
; 96(5): 758-61, 2007 Mar 12.
Article
em En
| MEDLINE
| ID: mdl-17311022
ABSTRACT
The potential utility of tumour-selective 5-fluorouracil treatment using attenuated Salmonella serovar typhimurium recombinant for cytosine deaminase (TAPET-CD) has been documented in experimental settings. The present data demonstrate that in vivo (19)F-magnetic resonance spectroscopy measurements allow the outcome prediction of this prokaryotic-based therapy, demonstrating the necessity of non-invasive real-time imaging techniques for treatment monitoring.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Terapia Genética
/
Citosina Desaminase
/
Flucitosina
/
Fluoruracila
/
Neoplasias Experimentais
/
Antineoplásicos
Tipo de estudo:
Prognostic_studies
Limite:
Animals
/
Female
/
Humans
Idioma:
En
Revista:
Br J Cancer
Ano de publicação:
2007
Tipo de documento:
Article
País de afiliação:
Holanda