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The products from lipase-catalysed hydrolysis of bovine milkfat kill Helicobacter pylori in vitro.
FEMS Immunol Med Microbiol ; 49(2): 235-42, 2007 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-17328757
ABSTRACT
Free fatty acids and monoglycerides released from milkfat by partial pregastric lipase-catalysed hydrolysis are bactericidal towards Helicobacter pylori. Two milkfat preparations were investigated: a normal bovine milkfat, and a fractionated milkfat preparation, termed ModFat, enriched in triglycerides containing short- and medium-chain fatty acids. The released products were tested for bactericidal potency against H. pylori. The potencies of the respective preparations were consistent with expected potencies calculated from individual free fatty acid and monoglyceride concentrations and their lauric acid equivalence factors (Ki). ModFat products were more bactericidal, in accordance with release of free fatty acid types of high potency, and addition of the surfactant Tween 80 to the hydrolysed lipid increased potency eight times more than did addition of lecithin. Tween 80 micelles have smaller aggregation numbers, and the mixed micelles of Tween 80/free fatty acids would be more likely to expose the bacteria to higher apparent free fatty acid concentrations.
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Coleções: Bases de dados internacionais Base de dados: MEDLINE Assunto principal: Helicobacter pylori / Leite / Lipase / Lipídeos / Antibacterianos Limite: Animais Idioma: Inglês Revista: FEMS Immunol Med Microbiol Assunto da revista: Alergia e Imunologia / Doenças Transmissíveis / Microbiologia Ano de publicação: 2007 Tipo de documento: Artigo País de afiliação: Nova Zelândia