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Is it worth using daclizumab induction therapy with mycophenolate mofetil-based immunosuppressive regimens in live related donor kidney transplantation? A long-term follow up.
Int Urol Nephrol ; 39(1): 317-9, 2007.
Artigo em Inglês | MEDLINE | ID: mdl-17333530
ABSTRACT

BACKGROUND/AIMS:

The aim of this work is to determine the long-term therapeutic benefit(s) of daclizumab induction therapy with triple immunosuppressive protocols including prednisolone, cyclosporine microemulsion (CsA), and mycophenolate mofetil (MMF) in the living related donor kidney transplantation.

METHODS:

Twenty-one adult recipients of their first kidney allograft were allocated to receive daclizumab with triple immunosuppressive therapy (steroids, CsA, and MMF). They were compared to 50 recipients of their first grafts who received a maintenance triple immunosuppressive therapy (steroids, CsA, and azathioprine). The patients were followed up for 5 years.

RESULTS:

Daclizumab group significantly experienced a marked reduction of acute rejection (7/21) when compared to the control group (31/50) with subsequent significant reduction of cumulative steroids doses at the end of 5 years. The overall incidence of post-transplant complications was comparable among the two treatment groups. There was no significant difference in patients and graft survival; 5-year patient and graft survival were 95.3%, 85.7% for daclizumab and 96%, 88% for control group, respectively.

CONCLUSIONS:

Although prophylactic daclizumab with triple immunosuppressive protocol including MMF have drastically reduced the incidence of acute rejections, the graft and patient survival are unchanged in this long-term follow up.
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Coleções: Bases de dados internacionais Base de dados: MEDLINE Assunto principal: Doadores de Tecidos / Imunoglobulina G / Transplante de Rim / Doadores Vivos / Imunossupressores / Anticorpos Monoclonais / Ácido Micofenólico Aspecto clínico: Prognóstico Limite: Adulto / Feminino / Humanos / Masculino Idioma: Inglês Revista: Int Urol Nephrol Ano de publicação: 2007 Tipo de documento: Artigo País de afiliação: Egito