A singular case of granulomatous lesions of unknown significance.
Minerva Med
; 99(2): 213-8, 2008 Apr.
Article
em En
| MEDLINE
| ID: mdl-18431329
ABSTRACT
The acronym used for granulomatous lesion of unknown significance, (GLUS), was first employed in 1990, to describe epithelioid-cell granulomas occasionally observed in biopsies from liver, lymph-nodes and other tissues without any apparent cause than thorough diagnostic examinations. Authors describe a case of a 51-year-old woman who was admitted to hospital because of fever, nodules in the liver and spleen, skin ulcerative lesions on the legs. The patient had a very long medical history; recurrent fever, liver and spleen enlargement have been lasting since 1975. Laboratory data showed erythrocyte sedimentation rate increase (125 mm 1 hour), anemia, (Hb=8.1 g/dL), an increase of alkaline phosphatase activity (328.4 mU/mL NV=80-275) and also an increase of policlonal gamma-globulins; patient's total proteins was 6.8 g/dL while their gamma-globulins were 29.5%; IgG=2 260 mg/dL (NV=751-1 560 mg/dL), IgM=277 mg/dL (NV=46-230 mg/dL), IgA=405 mg/dL (NV=70-400 mg/dL). One culture of the blood and a needle aspiration specimen of liver nodule was positive for Staphylococcus coagulase negative. This case cannot be regarded as GLUS-syndrome because of the long time duration of the disease and other clinical features. The dramatic, even if transient, liver nodules improvement obtained by Linezolid therapy, and the well-being obtained by prolonged monociclin use, make the authors hypothesize that Staphylococcus coagulase negative could be the etiological agent of this granulomatous clinical picture.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Úlcera Cutânea
/
Esplenopatias
/
Infecções Estafilocócicas
/
Granuloma
/
Hepatopatias
Limite:
Female
/
Humans
/
Middle aged
Idioma:
En
Revista:
Minerva Med
Ano de publicação:
2008
Tipo de documento:
Article
País de afiliação:
Itália