Hydrolytic degradation characteristics of irradiated multi-layered PLGA films.
Int J Pharm
; 360(1-2): 228-30, 2008 Aug 06.
Article
em En
| MEDLINE
| ID: mdl-18514448
ABSTRACT
Poly(lactide-co-glycolide) (PLGA) has been extensively investigated for controlled drug release. Because they undergo bulk degradation, they do not allow for a good controlled-release of drugs. The objective of this study is therefore to understand if a multi-layer-cum-irradiation technique would elicit surface erosion from PLGA polymers. A linear loss of mass and film thinning from PLGA films were observed. Also, the erosion of the top layer, of this multi-layered structure, accelerates degradation of the underlying layers. It is this effect that results in the observed pseudo-surface erosion for irradiated multi-layered PLGA.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ácido Poliglicólico
/
Ácido Láctico
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Excipientes
Idioma:
En
Revista:
Int J Pharm
Ano de publicação:
2008
Tipo de documento:
Article
País de afiliação:
Singapura
País de publicação:
HOLANDA
/
HOLLAND
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NETHERLANDS
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NL
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PAISES BAJOS
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THE NETHERLANDS