A randomised study of two doses of biosynthetic human growth hormone on final height of pubertal children with growth hormone deficiency.
Horm Res
; 70(2): 85-8, 2008.
Article
em En
| MEDLINE
| ID: mdl-18547954
ABSTRACT
AIMS:
To determine the effectiveness of different doses of r-hGH therapy during puberty in children with growth hormone deficiency (GHD).METHODS:
Randomized controlled trial of different doses of r-hGH therapy administered during puberty in 49 children with GHD. The patients were allocated randomly using a random number table to one of two groups group 1 (15 IU/m(2)/week) or group 2 (30 IU/m(2)/week). Patients were included if they had received r-hGH daily at a dose of 15 IU/m(2)/week (0.7 mg/m(2)/day) for at least 1 year before randomization.RESULTS:
Height increase standard deviation scores (SDS) were similar between the two groups (group 1 1.1; group 2 1.2; p = 0.81).CONCLUSION:
A higher dose of r-hGH administered during puberty does not appear to have a significant effect on final height of children with GH deficiency. Altering pubertal tempo or intensifying prepubertal r-hGH therapy may be a more promising approach to improving final height in children with GH deficiency.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Estatura
/
Hormônio do Crescimento Humano
Tipo de estudo:
Clinical_trials
Limite:
Adolescent
/
Child
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Horm Res
Ano de publicação:
2008
Tipo de documento:
Article
País de afiliação:
Reino Unido
País de publicação:
CH
/
SUIZA
/
SUÍÇA
/
SWITZERLAND