Immunohistochemical characterization of T-lymphocytes subsets in Egyptian hepatic schistosomiasis.
J Egypt Soc Parasitol
; 21(1): 195-202, 1991 Apr.
Article
em En
| MEDLINE
| ID: mdl-1903425
ABSTRACT
Liver biopsies from 20 schistosomal patients in the compensated stage were studied by immunoalkaline phosphatase technique for the relative distribution of T-cell subpopulations. T-cell subsets were defined for OKT3 (+) (pan T-lymphocytes), OKT4 (+) (helper-inducer), and OKT8 (+) (suppressor-cytotoxic) cell by using mouse hybridoma monoclonal antibodies. Sections showed marked pan T-lymphocytic infiltration predominantly in the portal tract within liver lobules and in the granulomatous lesions. Marked relative increment of suppressor/cytotoxic OKT8 (+) lymphocytes over the helper/inducer OKT4 (+) were observed. Alkaline phosphatase activity showed inverse significant correlation with OKT3 (+) and OKT8 (+) % and a direct significant correlation with OKT4 (+) % lymphocytes. This may suggest that suppressor cytotoxic OKT8 lymphocytes may be responsible for the modulation of the granulomata and stabilization of the morbidity state.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Esquistossomose mansoni
/
Subpopulações de Linfócitos T
/
Fígado
Limite:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
J Egypt Soc Parasitol
Ano de publicação:
1991
Tipo de documento:
Article
País de afiliação:
Egito
País de publicação:
EG
/
EGIPTO
/
EGITO
/
EGYPT