Recent synthetic approaches towards the antiproliferative natural products avrainvillamide and stephacidin B.
Chem Soc Rev
; 39(2): 591-9, 2010 Feb.
Article
em En
| MEDLINE
| ID: mdl-20111783
ABSTRACT
Due to their strong antiproliferative activity and their unprecedented structural complexity within the class of indole alkaloids, avrainvillamide and stephacidin B have recently attracted considerable interest from the synthetic community. To date, three distinct approaches towards these molecules have been disclosed and the present tutorial review aims at comparing all three syntheses with a focus on the various strategies and methods employed. Besides, recent progress towards the synthesis of structural analogs and the identification of the biological target of avrainvillamide will be presented.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Alcaloides Indólicos
/
Indóis
/
Antineoplásicos
Limite:
Humans
Idioma:
En
Revista:
Chem Soc Rev
Ano de publicação:
2010
Tipo de documento:
Article
País de afiliação:
Alemanha
País de publicação:
ENGLAND
/
ESCOCIA
/
GB
/
GREAT BRITAIN
/
INGLATERRA
/
REINO UNIDO
/
SCOTLAND
/
UK
/
UNITED KINGDOM