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Nondestructive imaging of individual biomolecules.
Phys Rev Lett ; 104(9): 095501, 2010 Mar 05.
Artigo em Inglês | MEDLINE | ID: mdl-20366992
ABSTRACT
Radiation damage is considered to be the major problem that still prevents imaging an individual biological molecule for structural analysis. So far, all known mapping techniques using sufficient short wavelength radiation, be it x rays or high energy electrons, circumvent this problem by averaging over many molecules. Averaging, however, leaves conformational details uncovered. Even the anticipated use of ultrashort but extremely bright x-ray bursts of a free electron laser shall afford averaging over 10{6} molecules to arrive at atomic resolution. Here, we present direct experimental evidence for nondestructive imaging of individual DNA molecules. In fact, we show that DNA withstands coherent low energy electron radiation with deBroglie wavelength in the Angstrom regime despite a vast dose of 10{8} electrons/nm{2} accumulated over more than one hour.

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Coleções: Bases de dados internacionais Base de dados: MEDLINE Idioma: Inglês Revista: Phys Rev Lett Ano de publicação: 2010 Tipo de documento: Artigo País de afiliação: Suíça