Global phosphoproteomics reveals crosstalk between Bcr-Abl and negative feedback mechanisms controlling Src signaling.

Rubbi, Liudmilla; Titz, Björn; Brown, Lauren; Galvan, Erica; Komisopoulou, Evangelia; Chen, Sharon S; Low, Tracey; Tahmasian, Martik; Skaggs, Brian; Müschen, Markus; Pellegrini, Matteo; Graeber, Thomas G

Rubbi, Liudmilla; Titz, Björn; Brown, Lauren; Galvan, Erica; Komisopoulou, Evangelia; Chen, Sharon S; Low, Tracey; Tahmasian, Martik; Skaggs, Brian; Müschen, Markus; Pellegrini, Matteo; Graeber, Thomas G.

Afiliação

Rubbi L; Crump Institute for Molecular Imaging; Institute for Molecular Medicine; Jonsson Comprehensive Cancer Center, California NanoSystems Institute, David Geffen School of Medicine, Department of Molecular & Medical Pharmacology, University of California, Los Angeles CA 90095, USA.
Titz B; Crump Institute for Molecular Imaging; Institute for Molecular Medicine; Jonsson Comprehensive Cancer Center, California NanoSystems Institute, David Geffen School of Medicine, Department of Molecular & Medical Pharmacology, University of California, Los Angeles CA 90095, USA.
Brown L; Crump Institute for Molecular Imaging; Institute for Molecular Medicine; Jonsson Comprehensive Cancer Center, California NanoSystems Institute, David Geffen School of Medicine, Department of Molecular & Medical Pharmacology, University of California, Los Angeles CA 90095, USA.
Galvan E; Crump Institute for Molecular Imaging; Institute for Molecular Medicine; Jonsson Comprehensive Cancer Center, California NanoSystems Institute, David Geffen School of Medicine, Department of Molecular & Medical Pharmacology, University of California, Los Angeles CA 90095, USA.
Komisopoulou E; Crump Institute for Molecular Imaging; Institute for Molecular Medicine; Jonsson Comprehensive Cancer Center, California NanoSystems Institute, David Geffen School of Medicine, Department of Molecular & Medical Pharmacology, University of California, Los Angeles CA 90095, USA.
Chen SS; Crump Institute for Molecular Imaging; Institute for Molecular Medicine; Jonsson Comprehensive Cancer Center, California NanoSystems Institute, David Geffen School of Medicine, Department of Molecular & Medical Pharmacology, University of California, Los Angeles CA 90095, USA.
Low T; Crump Institute for Molecular Imaging; Institute for Molecular Medicine; Jonsson Comprehensive Cancer Center, California NanoSystems Institute, David Geffen School of Medicine, Department of Molecular & Medical Pharmacology, University of California, Los Angeles CA 90095, USA.
Tahmasian M; Crump Institute for Molecular Imaging; Institute for Molecular Medicine; Jonsson Comprehensive Cancer Center, California NanoSystems Institute, David Geffen School of Medicine, Department of Molecular & Medical Pharmacology, University of California, Los Angeles CA 90095, USA.
Skaggs B; David Geffen School of Medicine, Division of Rheumatology, University of California, Los Angeles CA 90095, USA.
Müschen M; Department of Laboratory Medicine, University of California, San Francisco CA 94143, USA.
Pellegrini M; Institute for Genomics and Proteomics; Department of Molecular, Cell and Developmental Biology, University of California, Los Angeles CA 90095, USA.
Graeber TG; California NanoSystems Institute, University of California, Los Angeles CA 90095, USA.

Sci Signal ; 4(166): ra18, 2011 Mar 29.

Article em En | MEDLINE | ID: mdl-21447799

Assuntos

Resistencia a Medicamentos Antineoplásicos; Proteínas de Fusão bcr-abl/metabolismo; Leucemia/enzimologia; Proteínas Tirosina Quinases/metabolismo; Proteômica; Transdução de Sinais; Quinases da Família src/metabolismo; Proteínas Adaptadoras de Transdução de Sinal/genética; Proteínas Adaptadoras de Transdução de Sinal/metabolismo; Proteína Tirosina Quinase CSK; Linhagem Celular Transformada; Linhagem Celular Tumoral; Proteínas de Fusão bcr-abl/genética; Humanos; Leucemia/tratamento farmacológico; Leucemia/genética; Proteínas de Membrana/genética; Proteínas de Membrana/metabolismo; Fosforilação; Proteínas Tirosina Fosfatases não Receptoras/genética; Proteínas Tirosina Fosfatases não Receptoras/metabolismo; Proteínas Tirosina Quinases/genética; Proteínas Proto-Oncogênicas/genética; Proteínas Proto-Oncogênicas/metabolismo; Quinases da Família src/antagonistas & inibidores; Quinases da Família src/genética

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas Tirosina Quinases / Transdução de Sinais / Leucemia / Proteínas de Fusão bcr-abl / Quinases da Família src / Resistencia a Medicamentos Antineoplásicos / Proteômica Limite: Humans Idioma: En Revista: Sci Signal Assunto da revista: CIENCIA / FISIOLOGIA Ano de publicação: 2011 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Estados Unidos

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