[Association of IL-1beta gene -31T/C polymorphism with chronic rhinosinusitis].
Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
; 25(5): 197-200, 2011 Mar.
Article
em Zh
| MEDLINE
| ID: mdl-21604462
ABSTRACT
OBJECTIVE:
To investigate the relationship between polymorphism of IL-1beta gene 31T/C and chronic rhinosinusitis.METHOD:
One hundred and twenty-three patients with chronic rhinosinusitis and 239 healthy controls were collected to determine the genotypes by polymerase chain reaction-restriction fragment length polymorphism.RESULT:
There was significant difference in genotype and allelic frequencies between the CRS and control group (P < 0.05). -31CC genotype was an independent risk factor with CRS (P < 0.05, OR = 1.639). There was no significant difference in TIgE and ECP among these genotypes (P > 0.05).CONCLUSION:
IL-1beta gene 31CC genotype may be an independent risk factor with chronic rhinosinusitis.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Sinusite
/
Polimorfismo de Nucleotídeo Único
/
Interleucina-1beta
Tipo de estudo:
Observational_studies
/
Risk_factors_studies
Limite:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
Zh
Revista:
Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
Ano de publicação:
2011
Tipo de documento:
Article
País de afiliação:
China