[Association of IL-1beta gene -31T/C polymorphism with chronic rhinosinusitis].

ABSTRACT

OBJECTIVE: To investigate the relationship between polymorphism of IL-1beta gene 31T/C and chronic rhinosinusitis. METHOD: One hundred and twenty-three patients with chronic rhinosinusitis and 239 healthy controls were collected to determine the genotypes by polymerase chain reaction-restriction fragment length polymorphism. RESULT: There was significant difference in genotype and allelic frequencies between the CRS and control group (P < 0.05). -31CC genotype was an independent risk factor with CRS (P < 0.05, OR = 1.639). There was no significant difference in TIgE and ECP among these genotypes (P > 0.05). CONCLUSION: IL-1beta gene 31CC genotype may be an independent risk factor with chronic rhinosinusitis.