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RIT with Y90-Ibritumomab Tiuxetan in Follicular Non-Hodgkin Lymphoma: Evaluation of Recent Outcomes in a Single Institution.
J Oncol ; 2012: 412742, 2012.
Artigo em Inglês | MEDLINE | ID: mdl-23049552
ABSTRACT
Background. Based on historical data we reviewed our hospital clinical database to analyse our updated information and therapy outcomes of follicular non-Hodgkin lymphoma (F-NHL) patients treated with (90)Y-Ibritumomab tiuxetan. Patients and Methods. Between 2005 and 2011, 56 F-NHL patients were included in a clinical protocol conducted by a multidisciplinary team and treated in the same centre. All patients received 0.3 or 0.4 mCi/kg IV (88%) of (90)Y-IT; response evaluation was performed 12 weeks after. Results. M/F 44.6%/55.4%, mean age 61.45 years (30-85); ECOG 0-1 96.9%. According to FLIPI score, distribution were good 58.5%, intermediate 29.2%, and poor 12.3%. Previous therapies >2 40% (26). ORR was 94.6% (53/56). CR 85.7%; CR according to previous disease relapsed disease 90% (27/30), refractory disease 42.85% (3/7), consolidation with CR 92.85% (13/14), and consolidation with PR 100% (5/5). Global PR and NR were 8.9% (5) and 5.3% (3), respectively. Mean OS 63.86 months with a mean follow-up time of 57 months (2-73). Mean TTP 52.65 months (95% CI 43.83-61.48). Median OS and TTP were not achieved. No hospital submissions or deaths were registered. Conclusions. This study confirms the safety and high efficacy of (90)Y-IT in F-NHL patients, RIT in early stage of disease could improve outcomes.

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Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: MEDLINE Aspecto clínico: Prognóstico Idioma: Inglês Revista: J Oncol Ano de publicação: 2012 Tipo de documento: Artigo País de afiliação: Espanha