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[G6PD deficiency among children under 7 years old from Yunnan with unique ethnic minority origin].
Zhonghua Yi Xue Yi Chuan Xue Za Zhi ; 30(2): 189-94, 2013 Apr.
Artigo em Chinês | MEDLINE | ID: mdl-23568733

OBJECTIVE:

To investigate the epidemiological status of glucose-6-phosphate dehydrogenase (G6PD) deficiency among children from Yunnan with unique ethnic origins.

METHODS:

DNA samples from 11759 children were tested with fluorescent spot test, G6PD/6PGD quantitative ratio assay and hemoglobin electrophoresis.

RESULTS:

The detection rate of G6PD deficiency was 2.5%, for which boys were significantly greater than girls (3.5% vs. 1.4%, P<0.05). Significant differences were also detected among children from different ethnic groups and different regions. For ethnic Han Chinese, the detection rate was 0.7%, which was lower than the majority of ethnic minorities. By regression analysis, altitude of residence and family history both have significant influence on the calculated rate.

CONCLUSION:

Occurrence of G6PD deficiency seems to be influenced by gender. It also varies substantially between different ethnic groups as well as regions, e.g., more common in south. It also showed a declining trend after years of diagnosis and intervention. This survey may provide a valuable basis for counseling of G6PD deficiency in Yunnan.
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Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: MEDLINE Assunto principal: Deficiência de Glucosefosfato Desidrogenase Limite: Criança / Criança, pré-escolar / Feminino / Humanos / Lactente / Masculino / Recém-Nascido País/Região como assunto: Ásia Idioma: Chinês Revista: Zhonghua Yi Xue Yi Chuan Xue Za Zhi Assunto da revista: Genética Médica Ano de publicação: 2013 Tipo de documento: Artigo