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Therapeutic implications of mesenchymal stem cells in acute lung injury/acute respiratory distress syndrome.
Stem Cell Res Ther ; 4(3): 45, 2013 May 02.
Artigo em Inglês | MEDLINE | ID: mdl-23673003
ABSTRACT
Acute lung injury (ALI), and its more severe form, acute respiratory distress syndrome (ARDS), are syndromes of acute hypoxemic respiratory failure resulting from a variety of direct and indirect injuries to the gas exchange parenchyma of the lungs. Current treatment of ALI/ARDS is primarily supportive, with lung protective ventilation and fluid conserving strategies. Despite improvement in these strategies, recent data indicate that the mortality of ALI/ARDS is still as high as 30 to 50%. Thus, there is a need for innovative therapies to further improve clinical outcomes of ALI/ARDS. Recent studies involving the administration of mesenchymal stem cells (MSCs) for the treatment of experimental ALI/ARDS have shown promising results. This review focuses on existing studies that have tested the use of MSCs in models of ALI/ARDS, and the potential mechanisms underlying their therapeutic effects.
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Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: MEDLINE Assunto principal: Síndrome do Desconforto Respiratório do Adulto / Transplante de Células-Tronco Mesenquimais / Lesão Pulmonar Aguda Limite: Animais / Humanos Idioma: Inglês Revista: Stem Cell Res Ther Ano de publicação: 2013 Tipo de documento: Artigo