Regulation and expression of aberrant methylation on irinotecan metabolic genes CES2, UGT1A1 and GUSB in the in-vitro cultured colorectal cancer cells.

Xie, Fang-Wei; Peng, Yong-Hai; Chen, Xi; Chen, Xiong; Li, Jie; Yu, Zong-Yang; Wang, Wen-Wu; Ouyang, Xue-Nong

Xie, Fang-Wei; Peng, Yong-Hai; Chen, Xi; Chen, Xiong; Li, Jie; Yu, Zong-Yang; Wang, Wen-Wu; Ouyang, Xue-Nong.

Afiliação

Xie FW; Department of Medicine Oncology, Fuzhou General Hospital of Nanjing Military Command, 350025 Fuzhou, Fujian, China. Electronic address: zjxfw@vip.tom.com.
Peng YH; Department of Medicine Oncology, Fuzhou General Hospital of Nanjing Military Command, 350025 Fuzhou, Fujian, China.
Chen X; Department of Medicine Oncology, Fuzhou General Hospital of Nanjing Military Command, 350025 Fuzhou, Fujian, China.
Chen X; Department of Medicine Oncology, Fuzhou General Hospital of Nanjing Military Command, 350025 Fuzhou, Fujian, China.
Li J; Department of Medicine Oncology, Fuzhou General Hospital of Nanjing Military Command, 350025 Fuzhou, Fujian, China.
Yu ZY; Department of Medicine Oncology, Fuzhou General Hospital of Nanjing Military Command, 350025 Fuzhou, Fujian, China.
Wang WW; Department of Medicine Oncology, Fuzhou General Hospital of Nanjing Military Command, 350025 Fuzhou, Fujian, China.
Ouyang XN; Department of Medicine Oncology, Fuzhou General Hospital of Nanjing Military Command, 350025 Fuzhou, Fujian, China. Electronic address: oyxnong@163.com.

Biomed Pharmacother ; 68(1): 31-7, 2014 Feb.

Article em En | MEDLINE | ID: mdl-24439671

Assuntos

Antineoplásicos Fitogênicos/metabolismo; Camptotecina/análogos & derivados; Neoplasias Colorretais/genética; Glucuronosiltransferase/genética; Camptotecina/metabolismo; Carboxilesterase/genética; Neoplasias Colorretais/tratamento farmacológico; Neoplasias Colorretais/metabolismo; Metilação de DNA; Regulação Neoplásica da Expressão Gênica; Inativação Gênica; Glucuronidase/genética; Humanos; Irinotecano; Regiões Promotoras Genéticas/genética; RNA Mensageiro/metabolismo; Células Tumorais Cultivadas; Regulação para Cima/genética

Palavras-chave

Aberrant methylation; CES2; CPT-11; Colorectal cancer cell; GUSB; Gene expression; UGT1A1

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Camptotecina / Neoplasias Colorretais / Glucuronosiltransferase / Antineoplásicos Fitogênicos Limite: Humans Idioma: En Revista: Biomed Pharmacother Ano de publicação: 2014 Tipo de documento: Article País de publicação: França

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