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Diagnostic value of adenosine deaminase in ascites for tuberculosis ascites: a meta-analysis.
Diagn Microbiol Infect Dis ; 79(1): 102-7, 2014 May.
Artigo em Inglês | MEDLINE | ID: mdl-24629577
ABSTRACT
The diagnosis of tuberculosis (TB) ascites using standard diagnostic tools is difficult. The aim of the present meta-analysis was to establish the overall diagnostic accuracy of adenosine deaminase (ADA) levels in ascites for diagnosing TB ascites. A systematic review was performed of English language publications prior to April 2013. Sensitivity, specificity, and other measures of the accuracy of ADA for the diagnosis of TB ascites using ascites fluid were summarized using a random-effects model or a fixed-effects model. Receiver operating characteristic curves were used to summarize overall test performance. Seventeen studies involving 1797 subjects were eligible for the analysis. The summary estimates of sensitivity, specificity, positive likelihood ratio, negative likelihood ratio, diagnostic odds ratio, and the area under cure of overall analysis were: 0.93, 0.94, 13.55, 0.11, 169.83, and 0.976, respectively; the results of sensitivity analysis of studies that used Giusti method were 0.94, 0.94, 12.99, 0.08, 183.18, and 0.977, respectively. Our results suggest that ADA in the ascites can be a sensitive and specific target and a critical criterion for the diagnosis of TB ascites.
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Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: MEDLINE Assunto principal: Peritonite Tuberculosa / Líquido Ascítico / Adenosina Desaminase Tipo de estudo: Revisão sistemática Aspecto clínico: Diagnóstico Limite: Humanos Idioma: Inglês Revista: Diagn Microbiol Infect Dis Ano de publicação: 2014 Tipo de documento: Artigo