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A candidate gene study of capecitabine-related toxicity in colorectal cancer identifies new toxicity variants at DPYD and a putative role for ENOSF1 rather than TYMS.
Rosmarin, Dan; Palles, Claire; Pagnamenta, Alistair; Kaur, Kulvinder; Pita, Guillermo; Martin, Miguel; Domingo, Enric; Jones, Angela; Howarth, Kimberley; Freeman-Mills, Luke; Johnstone, Elaine; Wang, Haitao; Love, Sharon; Scudder, Claire; Julier, Patrick; Fernández-Rozadilla, Ceres; Ruiz-Ponte, Clara; Carracedo, Angel; Castellvi-Bel, Sergi; Castells, Antoni; Gonzalez-Neira, Anna; Taylor, Jenny; Kerr, Rachel; Kerr, David; Tomlinson, Ian.
Afiliação
  • Rosmarin D; Molecular and Population Genetics Laboratory, Oxford, UK Department of Oncology, University of Oxford, Old Road Campus Research Building, Oxford, UK.
  • Palles C; Molecular and Population Genetics Laboratory, Oxford, UK.
  • Pagnamenta A; Oxford NIHR Comprehensive Biomedical Research Centre, Wellcome Trust Centre for Human Genetics, Oxford, UK.
  • Kaur K; Oxford NIHR Comprehensive Biomedical Research Centre, Wellcome Trust Centre for Human Genetics, Oxford, UK.
  • Pita G; Human Genotyping Unit-CeGen, Human Cancer Genetics Programme, Spanish National Cancer Research Centre, Melchor Fernández Almagro 3, Madrid, Spain.
  • Martin M; Department of Medical Oncology, Instituto de Investigacion Sanitaria Hospital General Universitario Gregorio Marañón, Universidad Complutense, Madrid, Spain.
  • Domingo E; Molecular and Population Genetics Laboratory, Oxford, UK Oxford NIHR Comprehensive Biomedical Research Centre, Wellcome Trust Centre for Human Genetics, Oxford, UK.
  • Jones A; Molecular and Population Genetics Laboratory, Oxford, UK.
  • Howarth K; Molecular and Population Genetics Laboratory, Oxford, UK.
  • Freeman-Mills L; Molecular and Population Genetics Laboratory, Oxford, UK.
  • Johnstone E; Department of Oncology, University of Oxford, Old Road Campus Research Building, Oxford, UK.
  • Wang H; Department of Oncology, University of Oxford, Old Road Campus Research Building, Oxford, UK.
  • Love S; Centre for Statistics in Medicine, University of Oxford, Botnar Research Centre, Oxford, UK.
  • Scudder C; OCTO, University of Oxford, Old Road Campus Research Building, Oxford, UK.
  • Julier P; OCTO, University of Oxford, Old Road Campus Research Building, Oxford, UK.
  • Fernández-Rozadilla C; Molecular and Population Genetics Laboratory, Oxford, UK.
  • Ruiz-Ponte C; Galician Public Foundation of Genomic Medicine (FPGMX), CIBERER, Genomics Medicine Group, Hospital Clinico, University of Santiago de Compostela, Santiago de Compostela, Galicia, Spain.
  • Carracedo A; Galician Public Foundation of Genomic Medicine (FPGMX), CIBERER, Genomics Medicine Group, Hospital Clinico, University of Santiago de Compostela, Santiago de Compostela, Galicia, Spain.
  • Castellvi-Bel S; Genetic Susceptibility to Colorectal Cancer Group, Gastrointestinal & Pancreatic Oncology Team, IDIBAPS/CIBERehd/Hospital Clínic, Centre Esther Koplowitz (CEK), Barcelona, Spain.
  • Castells A; Institute of Digestive and Metabolic Diseases, Hospital Clínic, Barcelona, Spain.
  • Gonzalez-Neira A; Human Genotyping Unit-CeGen, Human Cancer Genetics Programme, Spanish National Cancer Research Centre, Melchor Fernández Almagro 3, Madrid, Spain.
  • Taylor J; Oxford NIHR Comprehensive Biomedical Research Centre, Wellcome Trust Centre for Human Genetics, Oxford, UK.
  • Kerr R; Department of Oncology, University of Oxford, Old Road Campus Research Building, Oxford, UK.
  • Kerr D; Nuffield Department of Clinical Laboratory Sciences, University of Oxford, Oxford, UK.
  • Tomlinson I; Molecular and Population Genetics Laboratory, Oxford, UK Oxford NIHR Comprehensive Biomedical Research Centre, Wellcome Trust Centre for Human Genetics, Oxford, UK.
Gut ; 64(1): 111-20, 2015 Jan.
Article em En | MEDLINE | ID: mdl-24647007
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Polimorfismo Genético / Timidilato Sintase / Neoplasias Colorretais / Proteínas / Di-Hidrouracila Desidrogenase (NADP) / Desoxicitidina / Estudos de Associação Genética / Fluoruracila / Antimetabólitos Antineoplásicos Limite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Gut Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Reino Unido País de publicação: Reino Unido
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Polimorfismo Genético / Timidilato Sintase / Neoplasias Colorretais / Proteínas / Di-Hidrouracila Desidrogenase (NADP) / Desoxicitidina / Estudos de Associação Genética / Fluoruracila / Antimetabólitos Antineoplásicos Limite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Gut Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Reino Unido País de publicação: Reino Unido