Two new phenolic compounds from Ficus rumphii and their antiproliferative activity.
Nat Prod Res
; 28(9): 646-52, 2014.
Article
em En
| MEDLINE
| ID: mdl-24666236
ABSTRACT
Two new compounds 2 and 4, along with two known compounds 1 and 3, were isolated for the first time from 95% ethanolic extract of the leaves of Ficus rumphii. Their structures were elucidated on the basis of chemical and physical evidences (elemental analysis, UV, IR, (1)H NMR, (13)C NMR and mass spectra) and comparison with the literature compounds. Structural authentication of compound 4 was further validated by single-crystal X-ray analysis and DFT calculations. The compounds 1-4 were screened for in vitro cytotoxicity against cancer and non-cancer cells and also tested for genotoxicity (comet assay). Compounds 2 and 4 displayed significant activity against HL-60 with IC50 values of 3.3 and 2.3 µM, respectively. The results revealed that compound 4 has better prospectus to act as cancer chemotherapeutic candidate which warrants further in vivo anticancer investigations.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fenóis
/
Piperidinas
/
Ficus
/
Antineoplásicos Fitogênicos
Limite:
Humans
País/Região como assunto:
Asia
Idioma:
En
Revista:
Nat Prod Res
Ano de publicação:
2014
Tipo de documento:
Article
País de afiliação:
Índia