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Synergy, compatibility, and innovation: merging Lewis acids with stereoselective enamine catalysis.
Chem Asian J ; 9(4): 984-95, 2014 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-24677815
ABSTRACT
In recent years there has been an accelerated rate of development in the field of organocatalysis, with asymmetric organocatalysis now reaching full maturity. The invention of new organocatalytic reactions and the exploration of new concepts now appear in tandem with the application of organocatalytic techniques in the synthesis of natural products and active pharmaceutical ingredients (APIs). After a "golden rush" in organocatalysis, researchers are now starting to combine different methods, thereby taking advantage of the significant benefits of synergy. Metals are used in combination with organocatalytic processes, thus reaching complexity that is found in nature, where enzymes take advantage of the presence of certain metals to increase the arsenal of organic transformations available. In this Focus review, we illustrate the possibility of a "happy marriage" between Lewis acids and organocatalytic stereoselective processes. Questions have been raised about the combination of Lewis acids and organocatalysis owing to the presence of water and/or strong bases in these processes. Some Lewis acids have been shown to be compatible with organocatalysis and concepts relating to their use will be illustrated herein. To summarize the fruitful use of Lewis acids in stereoselective organocatalytic processes, we will draw attention to the advantages and selectivity achieved using this method.
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Coleções: Bases de dados internacionais Base de dados: MEDLINE Assunto principal: Ácidos de Lewis Idioma: Inglês Revista: Chem Asian J Ano de publicação: 2014 Tipo de documento: Artigo