Your browser doesn't support javascript.
loading
Polymorphisms in FZD3 and FZD6 genes and risk of neural tube defects in a northern Han Chinese population.
Neurol Sci ; 35(11): 1701-6, 2014 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-24816679
ABSTRACT
Neural tube defects (NTDs) are the most common and severe malformations of the central nervous system. The association of single nucleotide polymorphisms (SNPs) of the Frizzled 3 (FZD3) and Frizzled 6 (FZD6) genes and NTDs in the Han population of northern China was principally studied. One synonymous SNP (rs2241802) in FZD3 gene and three nonsynonymous SNPs (rs827528, rs3808553 and rs12549394) in FZD6 gene were analyzed by polymerase chain reaction (PCR) and sequencing methods in 135 NTD patients and 135 normal controls. The allele, genotype and haplotype frequencies were calculated and analyzed to examine the relationship between FZD3/FZD6 SNPs and NTDs. Both T allele and TT genotype frequencies of the FZD6 rs3808553 loci in the NTDs group were significantly higher than those in the controls, and children with T allele and TT genotype were associated with increased NTDs risk (OR = 1.575, 95 % CI 1.112-2.230, P = 0.010 and OR = 2.811, 95 % CI 1.325-5.967, P = 0.023, respectively). There were no differences among different genotypes or alleles in other three SNPs. Haplotypes A-G-C and A-T-C in FZD6 were found associated with NTDs in the case-control study (OR = 0.560, 95 % CI 0.378-0.830, P = 0.004 and OR = 1.670, 95 % CI 1.126-2.475, P = 0.011, respectively). The rs3808553 of FZD6 is obviously associated with NTDs in Han population of northern China. The TT genotype may increase risk for NTDs.
Assuntos

Similares

MEDLINE

...
LILACS

LIS

Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: MEDLINE Assunto principal: Predisposição Genética para Doença / Polimorfismo de Nucleotídeo Único / Grupo com Ancestrais do Continente Asiático / Receptores Frizzled / Defeitos do Tubo Neural Tipo de estudo: Estudo de casos e controles Aspecto clínico: Etiologia Limite: Criança, pré-escolar / Feminino / Humanos / Masculino Idioma: Inglês Revista: Neurol Sci Assunto da revista: Neurologia Ano de publicação: 2014 Tipo de documento: Artigo País de afiliação: China