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Blood 2,5-dimethylfuran as a sensitive and specific biomarker for cigarette smoking.
Biomarkers; 19(6): 457-62, 2014 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-24980250
ABSTRACT

OBJECTIVE:

We evaluated the validity of blood 2,5-dimethylfuran (DMF) for determining smoking status using population-based data.

METHODS:

We obtained blood DMF concentrations and smoking status from National Health and Nutrition Examination Survey 2003-2006 and computed sensitivity, specificity and Kappa statistic.

RESULTS:

Self-reported smoking showed very high agreement (Kappa = 92.8-93.3%) in daily smokers and fair agreement in non-daily smokers (Kappa = 33.7-36.4%). Coffee intake did not influence the detection of blood DMF.

CONCLUSIONS:

Blood DMF has comparable sensitivity and specificity with serum cotinine for identifying current daily smokers, which may make it a useful biomarker in epidemiologic studies.
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Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: MEDLINE Assunto principal: Fumar / Furanos Aspecto clínico: Diagnóstico Limite: Adulto / Humanos / Meia-Idade / Jovem adulto Idioma: Inglês Revista: Biomarkers Assunto da revista: Bioquímica Ano de publicação: 2014 Tipo de documento: Artigo País de afiliação: Estados Unidos