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The effects of carbamazepine on prefrontal activation in manic youth with bipolar disorder.
Psychiatry Res ; 223(3): 268-70, 2014 Sep 30.
Artigo em Inglês | MEDLINE | ID: mdl-25035298
ABSTRACT
This preliminary study investigated the neurofunctional effects of carbamazepine-extended release (XR) treatment in 11 manic youth with bipolar disorder during performance of a sustained attention task, the Continuous Performance Task - Identical Pairs version (CPT-IP), during functional magnetic resonance imaging (fMRI). All patients underwent baseline fMRI, and 10 patients were scanned again at endpoint. Nine demographically matched healthy youth, who were scanned once, served as controls. Carbamazepine-XR treatment was associated with normalization of activation in right Brodmann area 10 (BA). These results suggest that carbamazepine-XR treatment may correct prefrontal dysfunction in adolescent mania.
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Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: MEDLINE Assunto principal: Atenção / Análise e Desempenho de Tarefas / Carbamazepina / Córtex Pré-Frontal / Antimaníacos Limite: Adolescente / Feminino / Humanos / Masculino Idioma: Inglês Revista: Psychiatry Res Ano de publicação: 2014 Tipo de documento: Artigo País de afiliação: Estados Unidos