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A common Greenlandic TBC1D4 variant confers muscle insulin resistance and type 2 diabetes.
Moltke, Ida; Grarup, Niels; Jørgensen, Marit E; Bjerregaard, Peter; Treebak, Jonas T; Fumagalli, Matteo; Korneliussen, Thorfinn S; Andersen, Marianne A; Nielsen, Thomas S; Krarup, Nikolaj T; Gjesing, Anette P; Zierath, Juleen R; Linneberg, Allan; Wu, Xueli; Sun, Guangqing; Jin, Xin; Al-Aama, Jumana; Wang, Jun; Borch-Johnsen, Knut; Pedersen, Oluf; Nielsen, Rasmus; Albrechtsen, Anders; Hansen, Torben.
Afiliação
  • Moltke I; 1] The Bioinformatics Centre, Department of Biology, University of Copenhagen, 2200 Copenhagen, Denmark [2] Department of Human Genetics, University of Chicago, Chicago, Illinois 60637, USA [3].
  • Grarup N; 1] The Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, 2100 Copenhagen, Denmark [2].
  • Jørgensen ME; Steno Diabetes Center, 2820 Gentofte, Denmark.
  • Bjerregaard P; National Institute of Public Health, University of Southern Denmark, 1353 Copenhagen, Denmark.
  • Treebak JT; The Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Integrative Physiology, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark.
  • Fumagalli M; Department of Integrative Biology, University of California, Berkeley, California 94720, USA.
  • Korneliussen TS; Centre for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, 1350 Copenhagen, Denmark.
  • Andersen MA; The Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Integrative Physiology, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark.
  • Nielsen TS; The Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Integrative Physiology, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark.
  • Krarup NT; The Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, 2100 Copenhagen, Denmark.
  • Gjesing AP; The Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, 2100 Copenhagen, Denmark.
  • Zierath JR; 1] The Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Integrative Physiology, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark [2] Department of Molecular Medicine and Surgery, Karolinska Institute, 171 77 Stockholm, Sweden.
  • Linneberg A; Research Centre for Prevention and Health, Glostrup University Hospital, 2600 Glostrup, Denmark.
  • Wu X; BGI-Shenzhen, Shenzhen 518083, China.
  • Sun G; BGI-Shenzhen, Shenzhen 518083, China.
  • Jin X; BGI-Shenzhen, Shenzhen 518083, China.
  • Al-Aama J; 1] BGI-Shenzhen, Shenzhen 518083, China [2] The Department of Genetic Medicine, Faculty of Medicine and Princess Al Jawhara Albrahim Center of Excellence in the Research of Hereditary Disorders, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
  • Wang J; 1] The Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, 2100 Copenhagen, Denmark [2] BGI-Shenzhen, Shenzhen 518083, China [3] The Department of Genetic Medicine, Faculty of Medicine and Princ
  • Borch-Johnsen K; Holbaek Hospital, 4300 Holbaek, Denmark.
  • Pedersen O; The Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, 2100 Copenhagen, Denmark.
  • Nielsen R; 1] Department of Integrative Biology, University of California, Berkeley, California 94720, USA [2] Department of Statistics, University of California, Berkeley, California 94720, USA.
  • Albrechtsen A; The Bioinformatics Centre, Department of Biology, University of Copenhagen, 2200 Copenhagen, Denmark.
  • Hansen T; 1] The Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, 2100 Copenhagen, Denmark [2] Faculty of Health Sciences, University of Southern Denmark, 5000 Odense, Denmark.
Nature ; 512(7513): 190-3, 2014 Aug 14.
Article em En | MEDLINE | ID: mdl-25043022
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Variação Genética / Resistência à Insulina / Proteínas Ativadoras de GTPase / Diabetes Mellitus Tipo 2 Tipo de estudo: Risk_factors_studies Limite: Adult / Humans / Middle aged País/Região como assunto: America do norte / Europa Idioma: En Revista: Nature Ano de publicação: 2014 Tipo de documento: Article País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
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XML
PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Variação Genética / Resistência à Insulina / Proteínas Ativadoras de GTPase / Diabetes Mellitus Tipo 2 Tipo de estudo: Risk_factors_studies Limite: Adult / Humans / Middle aged País/Região como assunto: America do norte / Europa Idioma: En Revista: Nature Ano de publicação: 2014 Tipo de documento: Article País de publicação: Reino Unido