Posttranslational protein modifications by reactive nitrogen and chlorine species and strategies for their prevention and elimination.
Free Radic Res
; 48(11): 1267-84, 2014 Nov.
Article
em En
| MEDLINE
| ID: mdl-25119970
ABSTRACT
Proteins are subject to various posttranslational modifications, some of them being undesired from the point of view of metabolic efficiency. Prevention of such modifications is expected to provide new means of therapy of diseases and decelerate the process of aging. In this review, modifications of proteins by reactive nitrogen species and reactive halogen species, is briefly presented and means of prevention of these modifications and their sequelae are discussed, including the denitrase activity and inhibitors of myeloperoxidase.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Envelhecimento
/
Proteínas
/
Cloro
/
Processamento de Proteína Pós-Traducional
/
Estresse Oxidativo
/
Espécies Reativas de Nitrogênio
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Free Radic Res
Assunto da revista:
BIOQUIMICA
Ano de publicação:
2014
Tipo de documento:
Article
País de afiliação:
Polônia
País de publicação:
ENGLAND
/
ESCOCIA
/
GB
/
GREAT BRITAIN
/
INGLATERRA
/
REINO UNIDO
/
SCOTLAND
/
UK
/
UNITED KINGDOM