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Cisplatin-induced testicular toxicity in rats: the protective effect of arjunolic acid.
J Biochem Mol Toxicol ; 28(11): 515-21, 2014 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-25130312
ABSTRACT
In the present study, the effect of arjunolic acid on testicular damage induced by intraperitoneal injection of rats with 7 mg/kg cisplatin was studied. Cisplatin induced a significant reduction in testicular weights, plasma testosterone, and testicular reduced glutathione levels in addition to a significant elevation of testicular malondialdehyde levels and testicular gene expressions of inducible nitric oxide synthase (iNOS), tumor necrosis factor-α (TNF-α), and p38 mitogen-activated protein kinase (MAPK) when compared with the control group (p < 0.05). Lower tubular diameters and depletion of germ cells and irregular small seminiferous tubules with Sertoli cells only were observed in the cisplatin group. Arjunolic acid administration significantly corrected the changes in both biochemical and histopathological parameters. Arjunolic acid plays a significant protective role against cisplatin-induced testicular injury by attenuating oxidative stress parameters along with downregulation of iNOS, TNF-α, and p38-MAPK testicular expressions.
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Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: MEDLINE Assunto principal: Testículo / Triterpenos / Cisplatino / Antineoplásicos Aspecto clínico: Terapia Limite: Animais / Humanos / Masculino Idioma: Inglês Revista: J Biochem Mol Toxicol Assunto da revista: Biologia Molecular / Bioquímica / Toxicologia Ano de publicação: 2014 Tipo de documento: Artigo País de afiliação: Egito