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[Effect of zige lyophilized powder for injection in improving acute cerebral microcirculation disturbance in rats].
Zhongguo Zhong Yao Za Zhi ; 39(4): 733-7, 2014 Feb.
Artigo em Chinês | MEDLINE | ID: mdl-25204156
ABSTRACT

OBJECTIVE:

To investigate the effect of Zige lyophilized powder for injection in improving the acute cerebral microcirculation disturbance in rats.

METHOD:

Window craniotomy was performed for rats after the drug administration for 14 days. The experimental microcirculation disturbance model was duplicated with high molecule dextran. After the drug administration, the micro-vein diameters of cerebral pla mater of various groups were observed and recorded under the biological microscope. The blood flow volume was monitored by laser Doppler flow-meter. HCT was measured by the electric resistance method. The hemorheological indexes were detected by the auto-hemorheological instrument.

RESULT:

Zige lyophilized powder for injection (16.40, 32.70, 65.40 mg x kg(-1)) could significantly expand the micro-vein diameter of cerebral pla mater, improve the downward trend of the blood flow volume, and reduce the various hemorheological indexes.

CONCLUSION:

Zige lyophilized powder for injection shows the effect in improving the cerebral microcirculation.
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Coleções: Bases de dados internacionais Base de dados: MEDLINE Assunto principal: Medicamentos de Ervas Chinesas / Isquemia Encefálica / Circulação Cerebrovascular Limite: Animais / Humanos / Masculino Idioma: Chinês Revista: Zhongguo Zhong Yao Za Zhi Assunto da revista: Farmacologia / Terapias Complementares Ano de publicação: 2014 Tipo de documento: Artigo