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[Research advances of IDH gene mutation and AML].
Zhongguo Shi Yan Xue Ye Xue Za Zhi ; 22(5): 1485-9, 2014 Oct.
Artigo em Chinês | MEDLINE | ID: mdl-25338613
The isocitrate dehydrogenase (IDH) gene mutation has been recently found, which may be involved in the occurrence of leukemia. The incidence of IDH gene mutation in the patients with adult acute myeloid leukemia (AML) is high, especially in the AML patients with normal karyotype. Different subtype and molecular biology of IDH display a different effect on the AML prognosis. This gene mutation is related with treatment response, residual, recurrence of leukemia, and it could be a sign of test and a monitoring tool of minimal residual disease (MRD). The IDH gene mutation may be an index for predicting prognosis and guiding therapy. In this article, the research progress of IDH gene mutation and its correlation with acute myeloid leukemia, especially with the clinical characteristics,are reviewed.
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Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: MEDLINE Assunto principal: Leucemia Mieloide Aguda / Isocitrato Desidrogenase / Mutação Aspecto clínico: Predição / Prognóstico Limite: Humanos Idioma: Chinês Revista: Zhongguo Shi Yan Xue Ye Xue Za Zhi Assunto da revista: Hematologia Ano de publicação: 2014 Tipo de documento: Artigo