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EuroTracker® dyes: design, synthesis, structure and photophysical properties of very bright europium complexes and their use in bioassays and cellular optical imaging.
Butler, Stephen J; Delbianco, Martina; Lamarque, Laurent; McMahon, Brian K; Neil, Emily R; Pal, Robert; Parker, David; Walton, James W; Zwier, Jurriaan M.
Afiliação
  • Butler SJ; Department of Chemistry, Durham University, South Road, Durham DH1 3LE, UK. david.parker@dur.ac.uk.
Dalton Trans ; 44(11): 4791-803, 2015 Mar 21.
Artigo em Inglês | MEDLINE | ID: mdl-25341077
ABSTRACT
The development of the brightest luminescent europium(iii) complexes is traced, including analysis of the C3-symmetric core complex based on a functionalized triazacyclononane and identification of the most suitable strongly absorbing chromophore. Strategies for the synthesis of the complexes, including enantiopure analogues, are outlined and opportunities for applications in time-resolved microscopy and spectral imaging emphasised. Practicable examples are introduced, including selective organelle staining for cellular optical imaging at 65 nm resolution and the development of new bioassays using time-resolved FRET methods.
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Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: MEDLINE Assunto principal: Compostos Organometálicos / Bioensaio / Corantes / Európio / Imagem Óptica Limite: Animais / Humanos Idioma: Inglês Revista: Dalton Trans Assunto da revista: Química Ano de publicação: 2015 Tipo de documento: Artigo País de afiliação: Reino Unido