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Design, synthesis, and biological activity of oxime ether strobilurin derivatives containing indole moiety as novel fungicide.
Chem Biol Drug Des ; 85(6): 743-55, 2015 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-25346294
ABSTRACT
Twenty-one novel oxime ether strobilurins containing indole moiety, which employed an indole group to stabilize the E-styryl group in Enoxastrobin, were designed and synthesized. The biological assay indicated that most compounds exhibited potent fungicidal activities. The structure-activity relationship study demonstrated that the synthesized methyl 3-methoxypropenoate oxime ethers 7b-e exhibited remarkably high activities among all the synthesized oxime ether compounds 7. Moreover, the fungicidal activities of methyl α-(methoxyimino)benzeneacetate oxime ethers compounds 7f-i and N-methoxy-carbamic acid methyl esters compounds 7j-m showed significant differences compared to the corresponding products of ammonolysis.
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Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: MEDLINE Assunto principal: Oximas / Fungos / Fungicidas Industriais / Indóis Idioma: Inglês Revista: Chem Biol Drug Des Assunto da revista: Bioquímica / Farmácia / Farmacologia Ano de publicação: 2015 Tipo de documento: Artigo País de afiliação: China