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PIK3R1 negatively regulates the epithelial-mesenchymal transition and stem-like phenotype of renal cancer cells through the AKT/GSK3ß/CTNNB1 signaling pathway.
Lin, Youcheng; Yang, Zhao; Xu, Abai; Dong, Pei; Huang, Yi; Liu, Huan; Li, Feida; Wang, Haifeng; Xu, Qian; Wang, Yongqiang; Sun, Da; Zou, Yong; Zou, Xiaowen; Wang, Yu; Zhang, Duo; Liu, Hongjie; Wu, Xun; Zhang, Meng; Fu, Yu; Cai, Zhiming; Liu, Chunxiao; Wu, Song.
Afiliação
  • Lin Y; Department of Urology, Zhujiang Hospital of Southern Medical University, Guangzhou 510280, China.
  • Yang Z; 1] CAS Key Laboratory of Infection and Immunity, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China [2] University of Chinese Academy of Sciences, Beijing 100049, China.
  • Xu A; Department of Urology, Zhujiang Hospital of Southern Medical University, Guangzhou 510280, China.
  • Dong P; Department of Urology, Sun Yat-Sen University Cancer Center, Guangzhou 510060, China.
  • Huang Y; National-Regional Key Technology Engineering Laboratory for Clinical Application of Cancer Genomics, Second People's Hospital, the First Affiliated Hospital of Shenzhen University, Shenzhen 518035, China.
  • Liu H; BGI-Shenzhen, Shenzhen 518083, China.
  • Li F; BGI-Shenzhen, Shenzhen 518083, China.
  • Wang H; Department of Urology, the Second Affiliated Hospital of Kunming Medical College, Kunming 650101, China.
  • Xu Q; Department of Oncology, the First Affiliated Hospital of Soochow University, Suzhou 215006, China.
  • Wang Y; National-Regional Key Technology Engineering Laboratory for Clinical Application of Cancer Genomics, Second People's Hospital, the First Affiliated Hospital of Shenzhen University, Shenzhen 518035, China.
  • Sun D; BGI-Shenzhen, Shenzhen 518083, China.
  • Zou Y; Department of Urology, Zhujiang Hospital of Southern Medical University, Guangzhou 510280, China.
  • Zou X; National-Regional Key Technology Engineering Laboratory for Clinical Application of Cancer Genomics, Second People's Hospital, the First Affiliated Hospital of Shenzhen University, Shenzhen 518035, China.
  • Wang Y; Department of Pathology, Zhujiang Hospital of Southern Medical University, Guangzhou 510280, China.
  • Zhang D; BGI-Shenzhen, Shenzhen 518083, China.
  • Liu H; BGI-Shenzhen, Shenzhen 518083, China.
  • Wu X; Department of Urology, Zhujiang Hospital of Southern Medical University, Guangzhou 510280, China.
  • Zhang M; National-Regional Key Technology Engineering Laboratory for Clinical Application of Cancer Genomics, Second People's Hospital, the First Affiliated Hospital of Shenzhen University, Shenzhen 518035, China.
  • Fu Y; National-Regional Key Technology Engineering Laboratory for Clinical Application of Cancer Genomics, Second People's Hospital, the First Affiliated Hospital of Shenzhen University, Shenzhen 518035, China.
  • Cai Z; National-Regional Key Technology Engineering Laboratory for Clinical Application of Cancer Genomics, Second People's Hospital, the First Affiliated Hospital of Shenzhen University, Shenzhen 518035, China.
  • Liu C; Department of Urology, Zhujiang Hospital of Southern Medical University, Guangzhou 510280, China.
  • Wu S; 1] National-Regional Key Technology Engineering Laboratory for Clinical Application of Cancer Genomics, Second People's Hospital, the First Affiliated Hospital of Shenzhen University, Shenzhen 518035, China [2] Department of Urology, Sun Yat-Sen University Cancer Center, Guangzhou 510060, China [3]
Sci Rep ; 5: 8997, 2015 Mar 11.
Article em En | MEDLINE | ID: mdl-25757764
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transdução de Sinais / Fosfatidilinositol 3-Quinases / Quinase 3 da Glicogênio Sintase / Proteínas Proto-Oncogênicas c-akt / Beta Catenina / Transição Epitelial-Mesenquimal / Neoplasias Renais Limite: Humans Idioma: En Revista: Sci Rep Ano de publicação: 2015 Tipo de documento: Article País de afiliação: China País de publicação: Reino Unido
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transdução de Sinais / Fosfatidilinositol 3-Quinases / Quinase 3 da Glicogênio Sintase / Proteínas Proto-Oncogênicas c-akt / Beta Catenina / Transição Epitelial-Mesenquimal / Neoplasias Renais Limite: Humans Idioma: En Revista: Sci Rep Ano de publicação: 2015 Tipo de documento: Article País de afiliação: China País de publicação: Reino Unido