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Rituximab, fludarabine, and cyclophosphamide versus fludarabine and cyclophosphamide for treatment of chronic lymphocytic leukemia: A systematic review with meta-analysis.
Crit Rev Oncol Hematol ; 94(3): 261-9, 2015 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-25797826


Chronic lymphocytic leukemia (CLL) is a disease of the lymphoid system, in which the most common therapy is fludarabine plus cyclophosphamide (FC). The addition of rituximab to FC has been used, a combination known as FCR.


To perform a systematic review with meta-analysis of clinical trials between 2000 and 2012 comparing FC and FCR in patients with CLL.


Electronic databases were searched using keywords related to the objectives of this review. The outcomes examined were progression-free survival and complete remission.


The progression-free survival and the overall survival showed significant difference between the two regimens, with complete remission being more frequent in FCR-treated patients (odds ratio=2.58; 95% CI: 2.13-3.13). Patients treated with FCR showed significantly higher neutropenia and serious adverse reactions.


Despite the favorable results of the FCR regimen on outcomes including complete remission, progression-free survival, and overall survival, there is a lack of methodological rigor and appropriate analyses in many of these studies, and thus, there is a need for further studies examining the effect of rituximab in CLL patients.





Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: MEDLINE Assunto principal: Leucemia Linfocítica Crônica de Células B / Protocolos de Quimioterapia Combinada Antineoplásica Tipo de estudo: Revisão sistemática Aspecto clínico: Terapia Limite: Humanos Idioma: Inglês Revista: Crit Rev Oncol Hematol Assunto da revista: Hematologia / Neoplasias Ano de publicação: 2015 Tipo de documento: Artigo