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Proanthocyanidins from the bark of Metasequoia glyptostroboides ameliorate allergic contact dermatitis through directly inhibiting T cells activation and Th1/Th17 responses.
Phytomedicine ; 22(4): 510-5, 2015 Apr 15.
Artigo em Inglês | MEDLINE | ID: mdl-25925974
ABSTRACT

OBJECTIVE:

The leaves and bark of Metasequoia glyptostroboides are used as anti-microbic, analgesic and anti-inflammatory drug for dermatic diseases in Chinese folk medicine. However, the pharmacological effects and material basis responsible for the therapeutic use of this herb have not yet been well studied. The objectives of this study were to evaluate the anti-inflammatory effects of the proanthocyanidin fraction from the bark of M. glyptostroboides (MGEB) and to elucidate its immunological mechanisms. MATERIALS AND

METHODS:

The anti-inflammatory activity of MGEB was evaluated using 2,4-dinitrofluorobenzene (DNFB)-induced allergic contact dermatitis (ACD) in mice. Its potential mechanisms were further investigated by determining its effects on Con A-induced T cell activation and Th1/Th17 responses in vitro.

RESULTS:

Both intraperitoneal injection and oral administration of MGEB significantly reduced the ear swelling in DNFB-induced ACD mice. MGEB inhibited Con A-induced proliferation and the expression levels of cell surface molecules CD69 and CD25 of T cells in vitro. MGEB also significantly decreased the production of Th1/Th17 specific cytokines (IL-2, IFN-γ and IL-17) and down-regulated their mRNA expression levels in activated T-cells.

CONCLUSIONS:

MGEB could ameliorate ACD, at least in part, through directly inhibiting T cells activation and Th1/Th17 responses.
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Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: MEDLINE Assunto principal: Extratos Vegetais / Ativação Linfocitária / Dermatite Alérgica de Contato / Cupressaceae / Proantocianidinas / Anti-Inflamatórios Limite: Animais Idioma: Inglês Revista: Phytomedicine Assunto da revista: Terapias Complementares Ano de publicação: 2015 Tipo de documento: Artigo País de afiliação: China