Second to fourth digit ratio (2D:4D) and coronary heart disease.
Early Hum Dev
; 91(7): 417-20, 2015 Jul.
Article
em En
| MEDLINE
| ID: mdl-25984655
ABSTRACT
INTRODUCTION:
Sex steroid exposure during human development may influence disease susceptibility. Second to fourth digit ratio (2D4D) is thought to be a putative biomarker for prenatal hormone level during foetal life. Recently there has been a great deal of interest in 2D4D and risk of disease in adulthood.METHODS:
We explored the relationship between 2D4D ratio and coronary heart disease. Photocopies of the two hands of 310 males (controls 155; patients 155) were collected at Yin chuan city, in the Ningxia province of China. Left hand, right hand, mean hand and right minus left 2D4D (Dr-l) were analysed.RESULTS:
The mean values of 2D4D ratio in patients were higher than those of CSIN controls. The patients showed significantly higher 2D4D (left hand P < 0.01; right hand, mean hand P < 0.05) than controls. In patients, 2D4D (especially left hand 2D4D) were inversely associated with age at diagnosis (left hand P < 0.001; right hand, mean hand P < 0.05). No association between Dr-l and age or age at presentation of disease was observed in the groups.CONCLUSION:
2D4D may correlate particularly with risk of coronary heart disease in Chinese men.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Caracteres Sexuais
/
Doença das Coronárias
/
Dedos
Tipo de estudo:
Etiology_studies
/
Risk_factors_studies
Limite:
Adult
/
Aged
/
Humans
/
Male
/
Middle aged
País/Região como assunto:
Asia
Idioma:
En
Revista:
Early Hum Dev
Ano de publicação:
2015
Tipo de documento:
Article