Analysis of Wnt and ß-catenin Expression in Advanced Colorectal Cancer.
Anticancer Res
; 35(8): 4403-10, 2015 Aug.
Article
em En
| MEDLINE
| ID: mdl-26168479
ABSTRACT
BACKGROUND:
Wnt/ß-catenin signaling plays an important role in colorectal cancer (CRC). Wnt has many sub-types and it is uncertain which of them affect progression of CRC. PATIENTS ANDMETHODS:
We analysed 201 patients who underwent curative surgery for CRC. We investigated the relationship between the expression of Wnt and ß-catenin proteins and prognosis using immunohistochemistry.RESULTS:
The high expression of Wnt1 correlated with high expression of nuclear and cytoplasmic ß-catenin (p=0.0004, p=0.02). The high expression of Wnt5a also correlated with high expression of membrane ß-catenin (p=0.03). In multivariate analysis, lymph node metastasis (p=0.046) and high expression of nuclear ß-catenin (p=0.04) were independent prognostic factors for survival.CONCLUSION:
The expression of nuclear ß-catenin is a useful predictive marker in CRC. It is suggested that Wnt1 may be the main activator of the ß-catenin signaling pathway and that Wnt5a may stabilize adherens junctions, thereby suppressing the epithelial-mesenchymal transition.Palavras-chave
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Colorretais
/
Proteínas Proto-Oncogênicas
/
Proteínas Wnt
/
Proteína Wnt1
/
Beta Catenina
/
Via de Sinalização Wnt
Tipo de estudo:
Prognostic_studies
Limite:
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Anticancer Res
Ano de publicação:
2015
Tipo de documento:
Article
País de afiliação:
Japão
País de publicação:
GR
/
GRECIA
/
GREECE
/
GRÉCIA