Your browser doesn't support javascript.
loading
Hydrofluorination of Alkynes Catalysed by Gold Bifluorides.
Nahra, Fady; Patrick, Scott R; Bello, Davide; Brill, Marcel; Obled, Alan; Cordes, David B; Slawin, Alexandra M Z; O'Hagan, David; Nolan, Steven P.
Afiliação
  • Nahra F; EaStCHEM School of Chemistry, University of St Andrews St Andrews, KY16 9ST (UK).
  • Patrick SR; EaStCHEM School of Chemistry, University of St Andrews St Andrews, KY16 9ST (UK).
  • Bello D; EaStCHEM School of Chemistry, University of St Andrews St Andrews, KY16 9ST (UK).
  • Brill M; EaStCHEM School of Chemistry, University of St Andrews St Andrews, KY16 9ST (UK).
  • Obled A; EaStCHEM School of Chemistry, University of St Andrews St Andrews, KY16 9ST (UK).
  • Cordes DB; EaStCHEM School of Chemistry, University of St Andrews St Andrews, KY16 9ST (UK).
  • Slawin AM; EaStCHEM School of Chemistry, University of St Andrews St Andrews, KY16 9ST (UK).
  • O'Hagan D; EaStCHEM School of Chemistry, University of St Andrews St Andrews, KY16 9ST (UK).
  • Nolan SP; EaStCHEM School of Chemistry, University of St Andrews St Andrews, KY16 9ST (UK).
ChemCatChem ; 7(2): 240-244, 2015 Jan.
Article em En | MEDLINE | ID: mdl-26236406
We report the synthesis of nine new N-heterocyclic carbene gold bifluoride complexes starting from the corresponding N-heterocyclic carbene gold hydroxides. A new methodology to access N,N'-bis(2,6-diisopropylphenyl)imidazol-2-ylidene gold(I) fluoride starting from N,N'-bis(2,6-diisopropylphenyl)imidazol-2-ylidene gold(I) hydroxide and readily available potassium bifluoride is also reported. These gold bifluorides were shown to be efficient catalysts in the hydrofluorination of symmetrical and unsymmetrical alkynes, thus affording fluorinated stilbene analogues and fluorovinyl thioethers in good to excellent yields with high stereo- and regioselectivity. The method is exploited further to access a fluorinated combretastatin analogue selectively in two steps starting from commercially available reagents.
Palavras-chave

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: ChemCatChem Ano de publicação: 2015 Tipo de documento: Article País de publicação: Alemanha

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: ChemCatChem Ano de publicação: 2015 Tipo de documento: Article País de publicação: Alemanha