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Cancer screening through a multi-analyte serum biomarker panel during health check-up examinations: Results from a 12-year experience.
Clin Chim Acta ; 450: 273-6, 2015 Oct 23.
Artigo em Inglês | MEDLINE | ID: mdl-26344337
ABSTRACT

BACKGROUND:

The use of blood-based tumor biomarkers for screening malignancies at early stages has significant advantages, including being convenient, automated, quantitative, objective, and relatively inexpensive compared with histology, endoscopy, and imaging.

METHODS:

We describe our 12-year experience on the diagnostic usefulness of a biomarker panel consisting of eight molecules (i.e., α-fetoprotein, carcinoembryonic antigen, prostate-specific antigen, CA 19-9, CA125, CA 15-3, squamous cell specific antigen, and cytokeratin 19 fragment) for cancer screening in Taiwanese subjects who underwent a health check-up examination at their own expenses.

RESULTS:

The sensitivity of the panel for the detection of specific cancers was higher than that of isolated cancer-specific markers. Specifically, the sensitivity of the panel for identifying the four most commonly diagnosed malignancies (i.e., liver cancer, lung cancer, prostate cancer, and colorectal cancer) was 90.9%, 75.0%, 100%, and 76.9%, respectively. The ability of the panel to detect early-stage (stage 1) hepatocellular carcinoma (HCC) or prostate cancer was similar to that observed for advanced malignancies.

CONCLUSIONS:

The multi-analyte biomarker panel is clinically useful during health check-up examinations for the screening of different tumors (especially for the early detection of HCC and prostate malignancies).
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Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: MEDLINE Assunto principal: Exame Físico / Biomarcadores Tumorais / Programas de Rastreamento / Detecção Precoce de Câncer / Neoplasias Aspecto clínico: Diagnóstico Limite: Adulto / Idoso / Feminino / Humanos / Masculino / Meia-Idade / Jovem adulto Idioma: Inglês Revista: Clin Chim Acta Ano de publicação: 2015 Tipo de documento: Artigo País de afiliação: Taiwan