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Intracellular PAF-Acetylhydrolase Type I.
Enzymes ; 38: 23-36, 2015.
Artigo em Inglês | MEDLINE | ID: mdl-26612644
Platelet-activating factor (PAF) is a phospholipid mediator whose synthesis and degradation depend on specific sets of enzymes. PAF-acetylhydrolase (PAF-AH) hydrolyzes the acetyl moiety of PAF at its sn-2 position and thereby inactivates it. PAF-AH Ib, originally identified in brain, exists in the cytoplasm of many (probably all) types of mammalian cells and tissues. PAF-AH Ib consists of three subunits (α1, α2, and ß), in which the α subunits provide the catalytic activity. The finding that the ß subunit is the product of the causative gene for Miller-Dieker lissencephaly led to extensive analyses of PAF-AH Ib subunits in the field of cell biology and neurobiology. More than 20 molecules are known to bind to PAF-AH Ib subunits, and PAF-AH Ib has been implicated in neuronal development, neuronal functions, Alzheimer's disease, bipolar disorder, cancer, spermatogenesis, and tolerance to hypoxia. However, in almost all of these cases, how the catalytic activity is involved and the identity of the most important substrate of this enzyme are unclear. In this chapter, the structure and functions of PAF-AH Ib and its subunit proteins are summarized and their contributions to human diseases are discussed.





Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: MEDLINE Idioma: Inglês Revista: Enzymes Ano de publicação: 2015 Tipo de documento: Artigo País de afiliação: Japão