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CUB and Sushi multiple domains 3 regulates dendrite development.
Neurosci Res ; 110: 11-7, 2016 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-27033969
ABSTRACT
CUB and Sushi multiple domains 3 (CSMD3) is a large protein expressed in fetal and adult brain. Recently, mutations of the CSMD3 gene were identified in schizophrenia and autism patients. However, biochemical properties and functions of the CSMD3 protein remain unknown. Here, we demonstrate that CSMD3 is an oligomeric type I transmembrane protein localized in the apical dendrites of hippocampal pyramidal neurons in the postnatal brain. In cultured hippocampal neurons, CSMD3 is expressed only after 7 days in vitro. Overexpression of CSMD3 induced dendritic branching in hippocampal neurons. Regulation of dendritic morphology by CSMD3 depended on the presence of its extracellular region, while CSMD3 intracellular region was dispensable for this activity. These results suggest that CSMD3 acts as a co-receptor of an unidentified membrane protein to regulate dendrite development. Therefore, malfunctions of CSMD3 may be one of the factors in the pathogenesis of psychiatric disorders.
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Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: MEDLINE Assunto principal: Dendritos / Proteínas de Membrana / Proteínas do Tecido Nervoso Limite: Animais Idioma: Inglês Revista: Neurosci Res Assunto da revista: Neurologia Ano de publicação: 2016 Tipo de documento: Artigo País de afiliação: Japão