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Changes of MDA and SOD in Brain Tissue after Secondary Brain Injury with Seawater Immersion in Rats.
Turk Neurosurg ; 26(3): 384-288, 2016.
Artigo em Inglês | MEDLINE | ID: mdl-27161465


To investigate the variation and significance of malondialdehyde (MDA) and superoxide dismutase (SOD) in brain tissue after secondary brain injury (SBI) with seawater immersion in rats. MATERIAL AND


We randomly divided 163 male Sprague Dawley rats into 4 groups, as normal (Group A), SBI (Group B), SBI with physiological saline immersion (Group C) and SBI with seawater immersion (Group D) groups. The animal model of ischemic SBI with seawater immersion was established based on the Marmarou's model of diffuse brain injury. The water content, and the MDA and SOD contents of brain tissue were detected at 1, 3, 6, 12, 24 and 48 hours after the injury.


Compared to group A, there were significant changes of various indicators in group D after injury at 1 hour after injury (P < 0.05). The water content and MDA contents in brain tissue were persistently elevated and significantly higher than that in groups B and C at each time phase (P < 0.05). The SOD content showed a persistent decline and was significantly lower than that in groups B and C at each time phase (P < 0.05). The SOD content was negatively correlated with the MDA content with a correlation coefficient of -0.992 (P < 0.01).


The SBI with seawater immersion is faster and more serious than the simple SBI.





Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: MEDLINE Assunto principal: Água do Mar / Superóxido Dismutase / Química Encefálica / Lesões Encefálicas / Imersão / Malondialdeído Limite: Animais Idioma: Inglês Revista: Turk Neurosurg Assunto da revista: Neurocirurgia Ano de publicação: 2016 Tipo de documento: Artigo País de afiliação: China