Safety of histamine-2 receptor blockers in hospitalized VLBW infants.
Early Hum Dev
; 99: 27-30, 2016 08.
Article
em En
| MEDLINE
| ID: mdl-27390109
ABSTRACT
BACKGROUND:
Histamine-2 receptor (H2) blockers are often used in very low birth weight infants despite lack of population specific efficacy and safety data.AIMS:
We sought to describe safety and temporal trends in histamine-2 receptor (H2) blocker use in hospitalized very low birth weight (VLBW) infants. STUDYDESIGN:
We conducted a retrospective cohort study using a clinical database populated by an electronic health record shared by 348 neonatal intensive care units in the United States.SUBJECTS:
We included all VLBW infants without major congenital anomalies. OUTCOMEMEASURES:
We used multivariable logistic regression with generalizing estimating equations to evaluate the association between days of H2 blocker exposure and risk of 1) death or necrotizing enterocolitis (NEC); 2) death or sepsis; and 3) death, NEC, or sepsis.RESULTS:
Of 127,707 infants, 20,288 (16%) were exposed to H2 blockers for a total of 6,422,352days. Median gestational age for infants exposed to H2 blockers was 27weeks (25th 75th percentile 26, 29). H2 blocker use decreased from 18% of infants in 1997 to 8% in 2012 (p<0.001). On multivariable analysis, infants were at increased risk of the combined outcome of death, NEC, or sepsis on days exposed to H2 blockers (odds ratio=1.14) (95% confidence interval 1.08, 1.19).CONCLUSIONS:
H2 blocker use is associated with increased risk of the combined outcome of death, NEC, or sepsis in hospitalized VLBW infants.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Mortalidade Infantil
/
Recém-Nascido de muito Baixo Peso
/
Antagonistas dos Receptores H2 da Histamina
Tipo de estudo:
Etiology_studies
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Observational_studies
/
Risk_factors_studies
Limite:
Female
/
Humans
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Infant
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Male
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Newborn
Idioma:
En
Revista:
Early Hum Dev
Ano de publicação:
2016
Tipo de documento:
Article