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The Interplay Between Conformation and Absolute Configuration in Chiral Electron Dynamics of Small Diols.
Angew Chem Int Ed Engl ; 55(37): 11054-8, 2016 09 05.
Artigo em Inglês | MEDLINE | ID: mdl-27445202
A competition between chiral characteristics alternatively attributable to either conformation or to absolute configuration is identified. Circular dichroism associated with photoexcitation of the outer orbital of configurational enantiomers of 1,3- and 2,3-butanediols has been examined with a focus on the large changes in electron chiral asymmetry produced by different molecular conformations. Experimental gas-phase measurements offer support for the theoretical modeling of this chiroptical effect. A surprising prediction is that a conformationally produced pseudo-enantiomerism in 1,3-butanediol generates a chiral response in the frontier electron dynamics that outweighs the influence of the permanent configurational handedness established at the asymmetrically substituted carbon. Induced conformation, and specifically induced conformational chirality, may thus be a dominating factor in chiral molecular recognition in such systems.





Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: MEDLINE Aspecto clínico: Predição / Prognóstico Idioma: Inglês Revista: Angew Chem Int Ed Engl Ano de publicação: 2016 Tipo de documento: Artigo País de afiliação: Reino Unido