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Three new alkaloids from Veratrum grandiflorum Loes with inhibition activities on Hedgehog pathway.
Bioorg Med Chem Lett ; 26(19): 4735-4738, 2016 10 01.
Artigo em Inglês | MEDLINE | ID: mdl-27567371
ABSTRACT
Three new steroidal alkaloids 1-3, together with four known compounds 4-7, were isolated from the ethanol extract of Veratrum grandiflorum Loes. Their structures were elucidated by NMR (1D and 2D NMR) and MS spectroscopic data. The inhibition activities on Hedgehog (Hh) pathway were evaluated using a cell-based bioassay system (Shh-LIGHT 2 cells). The results showed that compounds 1-3 and 5 displayed inhibitory activities obviously with the IC50 values of 0.63-3.11µM. Among them, compound 5 showed the most prominent inhibition activity (IC50=0.63±0.02µM). Thus, these active alkaloids may be potent natural compounds as Hh pathway inhibitors for the treatment of various cancers.
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Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: MEDLINE Assunto principal: Veratrum / Alcaloides de Veratrum / Proteínas Hedgehog Limite: Humanos Idioma: Inglês Revista: Bioorg Med Chem Lett Assunto da revista: Bioquímica / Química Ano de publicação: 2016 Tipo de documento: Artigo