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Cu(II), Ni(II) complexes derived from chiral Schiff-base ligands: Synthesis, characterization, cytotoxicity, protein and DNA-binding properties.
J Photochem Photobiol B ; 163: 403-12, 2016 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-27619741
ABSTRACT
A series of novel copper (II) and nickel (II) complexes derived from chiral Schiff-base ligands [(R)/(S)-H2L(1)=(R)/(S)-2-[(1-Hydroxymethyl-propylimino)-methyl]-5-methoxy-phenol and (R)/(S)-H2L(2)=(R)/(S)-2-[(1-Hydroxymethyl-2-phenyl-ethylimino)-methyl]-5-methoxy-phenol], were synthesized and characterized by elemental analyses, (1)H NMR spectra, FT-IR spectrum. The crystal structures of complexes 1-5 were determined through single crystal X-ray diffraction (SXRD). The structures showed the ligands coordinated to the Cu/Ni (II) ion in a neutral manner via ONO donor atoms, and oxygen atoms of solvent molecules occupy the axial positions in Ni (II) complexes 3 and 4. The complexes interactions with BSA and CT-DNA were investigated by various spectroscopic methods (UV-Visible, circular dichroism spectrum, fluorescence spectroscopic and synchronous fluorescence spectra). Interactions of chiral copper (II) complexes are stronger than nickel (II) complexes. Further, the cytotoxicities of the complexes 1-6 towards three kinds of cancerous cell lines, were human lung adenocarcinoma (A549), human cervical carcinoma cell (HeLa) and human breast cancer cell (MCF-7) respectively, were evaluated by MTT assay. All complexes exhibited good cytotoxic activity. Furthermore, Cu (II) complex 5 derived from (R)-Schiff-base ligand was found to be more effective towards HeLa cancerous cell. The results showed that chirality and metal ion have important influence on their anticancer activities and interactions with DNA/BSA.
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Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: MEDLINE Assunto principal: Compostos Organometálicos / DNA / Soroalbumina Bovina / Cobre / Níquel Limite: Humanos Idioma: Inglês Revista: J Photochem Photobiol B Assunto da revista: Biologia Ano de publicação: 2016 Tipo de documento: Artigo País de afiliação: China