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Mechanism-Based Strategies for the Management of Autoimmunity and Immune Dysregulation in Primary Immunodeficiencies.
J Allergy Clin Immunol Pract ; 4(6): 1089-1100, 2016.
Artigo em Inglês | MEDLINE | ID: mdl-27836058
ABSTRACT
A broad spectrum of autoimmunity is now well described in patients with primary immunodeficiencies (PIDs). Management of autoimmune disease in the background of PID is particularly challenging given the seemingly discordant goals of immune support and immune suppression. Our growing ability to define the molecular underpinnings of immune dysregulation has facilitated novel targeted therapeutics. This review focuses on mechanism-based treatment strategies for the most common autoimmune and inflammatory complications of PID including autoimmune cytopenias, rheumatologic disease, and gastrointestinal disease. We aim to provide guidance regarding the rational use of these agents in the complex PID patient population.
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Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: MEDLINE Assunto principal: Doenças Autoimunes / Gastroenteropatias / Síndromes de Imunodeficiência Limite: Animais / Humanos Idioma: Inglês Revista: J Allergy Clin Immunol Pract Ano de publicação: 2016 Tipo de documento: Artigo País de afiliação: Marrocos