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Cytocompatibility testing of cyclodextrin-functionalized antimicrobial textiles-a comprehensive approach.
Reddersen, Kirsten; Finger, Susanne; Zieger, Michael; Wiegand, Cornelia; Buschmann, Hans-Jürgen; Elsner, Peter; Hipler, Uta-Christina.
Afiliação
  • Reddersen K; Department of Dermatology, University Hospital Jena, Jena, Germany. kirsten.reddersen@med.uni-jena.de.
  • Finger S; Department of Dermatology, University Hospital Jena, Jena, Germany.
  • Zieger M; Department of Dermatology, University Hospital Jena, Jena, Germany.
  • Wiegand C; Department of Dermatology, University Hospital Jena, Jena, Germany.
  • Buschmann HJ; Deutsches Textilforschungszentrum Nord-West e.V. Krefeld, Krefeld, Germany.
  • Elsner P; Department of Dermatology, University Hospital Jena, Jena, Germany.
  • Hipler UC; Department of Dermatology, University Hospital Jena, Jena, Germany.
J Mater Sci Mater Med ; 27(12): 190, 2016 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-27844305
ABSTRACT
Functionalized textiles can be used in wound management to reduce the microbial burden in the wound area, to prevent wound infections, and to avoid cross-contamination between patients. In the present study, a comprehensive in vitro approach to enable the assessment of antibacterial activity of functionalized textiles and cytotoxicity of cyclodextrin (CD)-complexes with chlorhexidine diacetate (CHX), iodine (IOD), and polihexanide (PHMB) is suggested to evaluate their properties for supporting optimal conditions for wound healing. For all ß-CD-antiseptic functionalized cotton samples a strong antibacterial effect on the Gram-positive bacteria Staphylococcus aureus and Staphylococcus epidermidis as well as on the Gram-negative bacteria Klebsiella pneumoniae and Escherichia coli was proven. In addition, ß-CD-CHX and ß-CD-PHMB were effective against the yeast Candida albicans. The growth of Pseudomonas aeruginosa could be reduced significantly by ß-CD-IOD and ß-CD-PHMB. The established comprehensive testing system for determination of biocompatibility on human HaCaT keratinocytes is suitable for obtaining robust data on cell viability, cytotoxicity and mode of cell death of the ß-CD-antiseptic-complexes. The promising results of the high antimicrobial activity of these functionalized textiles show the high potential of such materials in medical applications.
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Coleções: Bases de dados internacionais Contexto: Doenças neglicenciadas Tema em saúde: Zoonoses Base de dados: MEDLINE Assunto principal: Têxteis / Infecções Bacterianas / Materiais Biocompatíveis / Ciclodextrinas / Anti-Infecciosos Limite: Humanos Idioma: Inglês Revista: J Mater Sci Mater Med Assunto da revista: Engenharia Biomédica Ano de publicação: 2016 Tipo de documento: Artigo País de afiliação: Alemanha