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ABSTRACT
We analyzed the in silico purified DNA methylation signatures of 82 mantle cell lymphomas (MCL) in comparison with cell subpopulations spanning the entire B cell lineage. We identified two MCL subgroups, respectively carrying epigenetic imprints of germinal-center-inexperienced and germinal-center-experienced B cells, and we found that DNA methylation profiles during lymphomagenesis are largely influenced by the methylation dynamics in normal B cells. An integrative epigenomic approach revealed 10,504 differentially methylated regions in regulatory elements marked by H3K27ac in MCL primary cases, including a distant enhancer showing de novo looping to the MCL oncogene SOX11. Finally, we observed that the magnitude of DNA methylation changes per case is highly variable and serves as an independent prognostic factor for MCL outcome.
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Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: MEDLINE Assunto principal: Elementos Facilitadores Genéticos / Metilação de DNA / Linfoma de Célula do Manto / Sequenciamento de Nucleotídeos em Larga Escala / Epigenômica Aspecto clínico: Prognóstico Limite: Humanos Idioma: Inglês Revista: Cancer Cell Assunto da revista: Neoplasias Ano de publicação: 2016 Tipo de documento: Artigo País de afiliação: Espanha