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Recent progression in the utilization of autophagy-regulating nature compound as anti-liver fibrosis agents.
J Asian Nat Prod Res ; 19(2): 109-113, 2017 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-28133978
ABSTRACT
Hepatic fibrosis is a wound-healing response to chronic liver injury caused by various pathogenesis, such as hepatitis virus infection, drugs toxicity and autoimmune imbalances. Autophagy, a cellular process degrading damaged organelles or aggregative proteins, participates in multiple human diseases including hepatic fibrosis. However, the precise role of autophagy in the pathogenesis of hepatic fibrosis is yet to be elucidated. Accumulated evidences indicate that several nature compounds exhibit anti-fibrotic potential through modulating autophagy activity. For a better understanding of the relationships among autophagy, hepatic fibrosis, and autophagy-regulating nature compounds, this review highlights the recent advancement of nature compounds treating hepatic fibrosis through regulating autophagy.
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Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: MEDLINE Assunto principal: Autofagia / Cirrose Hepática Limite: Animais / Humanos Idioma: Inglês Revista: J Asian Nat Prod Res Assunto da revista: Botânica / Química Ano de publicação: 2017 Tipo de documento: Artigo País de afiliação: China